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培美曲塞治疗晚期NSCLC的临床观察:52例近期疗效报告 被引量:1

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摘要 全球范围内每年约有140万人被诊断为肺癌,其中80%为非小细胞肺癌(NSCLC)。培美曲塞是一种新型抗叶酸代谢细胞毒药物,该药物和它的多聚谷氨酸盐能竞争性抑制胸腺嘧啶核苷酸合成酶(TS)、二氢叶酸还原酶(DHFR)以及甘氨酰胺核苷酸甲基转移酶(GARFT)等叶酸依赖性酶,造成叶酸代谢和核苷酸合成过程的异常,抑制肿瘤细胞生长。
出处 《中国老年保健医学》 2011年第2期42-43,共2页 Chinese Journal of Geriatric Care
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