通心络胶囊对实验家兔动脉粥样硬化腹主动脉NF-κB的影响

The effect of tongxinluo capsule on NF-κB of abdominal aortic in laboratory rabbit with atherosclerosis

目的通过构建家兔主动脉粥样硬化类型,观察通心络胶囊对家兔动脉粥样硬化腹主动脉核因子-κB(NF-κB)的影响。方法通过高脂+高胱氨酸饮食制作家兔动脉粥样硬化模型,灌药组分为通心络组、复方丹参滴丸组,同时设空白对照组和模型对照组,利用免疫组化技术检测各组动物腹主动脉平滑肌内核因子-κB(NF-κB)阳性细胞率。结果家兔动脉粥样硬化腹主动脉NF-κB阳性率表达,模型对照组>丹参滴丸组>通心络组>空白对照组,组间两两比较差异均有统计学意义(P<0.01或P<0.05)。结论通心络胶囊能抑制家兔动脉粥样硬化腹主动脉平滑肌NF-κB的表达,是其稳定易损斑块的可能作用靶点之一。

Objective By building type of atherosclerosis in rabbit,to observe the effect of tongxinluo capsule on NF-κB of abdominal aortic in laboratory rabbit with atherosclerosis.Methods Through the production of high-fat diet＋high cystine made rabbit atherosclerosis model,perfusion group was divided into tongxinluo group,compound danshen dripping pills（DSP） group,while made blank control group and model control group,used of immunohistochemical technique to detect positive cell rate of nuclear factor-κB（NF-κB） of each groups.Results The NF-κB positive rate of abdominal aortic in rabbits with atherosclerosis,model control groupDSP grouptongxinluo groupblank control group,compared with any two groups（P0.01 or P0.05） .Conclusion Tongxinluo capsule can inhibit the expression of NF-κB of abdominal aortic in laboratory rabbit with atherosclerosis,is one the possible role of target of the stability vulnerable plaque.