辛伐他汀短期干预对不稳定型心绞痛炎性因子的影响

Influence of short-term intervention of simvastatin on inflammatory factors in patient with unstable angina pectoris

目的观察辛伐他汀短期干预对不稳定型心绞痛患者C反应蛋白(CRP)及肿瘤坏死因子α(TNFα)的影响。方法采用随机对照的方法将79例不稳定型心绞痛患者分为辛伐他汀治疗A组27例和辛伐他汀治疗B组26例及对照组26例。对照组给予不稳定型心绞痛的一般治疗,不予任何降脂药物;辛伐他汀治疗A组在上述基础上加用辛伐他汀,每天20mg;辛伐他汀治疗B组加用辛伐他汀,每天40mg。治疗1周后比较3组CRP及TNFα水平变化。结果对照组治疗前后血清CRP、TNFα水平比较差异均无统计学意义(P>0.05);治疗A组及治疗B组治疗后较治疗前血清CRP、TNFα水平明显下降,差异均有统计学意义(P<0.05)。治疗A组治疗后与血清CRP、TNFα水平与对照组比较差异无统计学意义(P>0.05);治疗组B组治疗后CRP和TNFα水平与对照组比较差异有统计学意义(P<0.05)。结论大剂量辛伐他汀短期干预可阻滞不稳定型心绞痛患者冠状动脉病变的炎性反应。

Objective To observe the influence of the short-term intervention of simvastatin on C-reactive protein（CRP） and tumor putrescence factorα（TNFα） in patient with unstanble angina pectoris.Methods 79 cases patients with unstable angina pectoris were randomized into control group（52 cases） ,simvastatin treatment A group（27 cases） and simvastatin treatment B group（26 cases） .Control group just only accepted routine therapy of unstable angina pectoris except non-lipid-lowering drugs;Simvastatin treatment A group accepted simavastatin 20mg every day besides routine therapy and simvastatin treatment B group accepted simvastatin 40mg every day.After treatment,compared the level of CRP and TNFα of the three groups.Results Before and after treatment,the level of CRP,TNFα of control group were no significant difference（P0.05） .After treatment,the level of CRP and TNFα of treatment A and B group decreased respectively（P0.05） .After treatment,compared to control group,the level of CRP and TNFα of treatment A group were no significant difference（P0.05）;The level of CRP and TNFα of treatment B group were significant difference（P0.05） .Conclusion Short-term intervention of great dose of simvastatin can prevent the inflammatory reaction of coronary artery disease in unstable angina pectoris.