线性扫描极谱法测定消旋山莨菪碱

Linear Scanning Polarographic Determination of Raceanisodamine

用线性扫描极谱法和循环伏安法研究了消旋山莨菪碱在0.3mol·L^(-1)磷酸氢二钠-磷酸二氢钾缓冲溶液(pH 6.70)中的电化学行为。消旋山莨菪碱于-1.095V(vs.SCE)处产生一灵敏的吸附波,消旋山莨菪碱质量浓度在0.10～10.0mg·L^(-1)范围内与其一次微分线性扫描峰电流i_p呈线性关系,检出限(3S/N)为0.06mg·L^(-1)。对5.0mg·L^(-1)消旋山莨菪碱溶液进行6次平行试验,相对标准偏差为0.34%,该方法用于片剂中消旋山莨菪碱含量的测定,测定值与标示值相符。

Electrochemical behavior of receanisodamine was studied by linear scanning polarography and cyclic voltammetry.In a PBS of pH 6.70,a sensitive adsorptive wave of Raceanisodamine was observed at the potential of -1.095V（vs.SCE）.Linear relationship between values of 1st derivative peak current and concentration of raceanisodamine was kept in the range of 0.10-10.0 mg·L^-1,with its detection limit（3S/N）of 0.06 mg·L^-1. Precision was tested at the concentration level of 5.0 mg·L^-1,value of RSD（n=6）found was 0.34%.The method was used in the analysis of raceanisodamine tablets,giving results in consistency with the labelled value.