Clusterin和Syk在大肠癌中的表达及意义

Expression of Clusterin and Spleen Tyrosine Kinase in Colorectal Carcinoma and its Significance

[目的]分析凋亡相关因子Clusterin和脾酪氨酸激酶(Syk)与大肠癌生物学行为的关系。[方法]应用免疫组化法检测80例大肠癌组织和癌周正常组织中Clusterin和Syk表达水平。[结果]Clusterin在正常大肠组织中表达率为10.00%(8/80),在大肠癌组织中的表达率为71.25%(57/80),两者比较有显著性差异(P<0.01)。Syk在正常大肠组织中表达率为92.50%(74/80),在大肠癌组织中的表达率为35.00%(28/80),两者比较有显著性差异(P<0.01)。Clusterin表达与大肠癌分化程度、浸润深度、TNM分期、淋巴结转移有关(P<0.05),Syk表达水平与大肠癌浸润深度、TNM分期、淋巴结转移有关(P<0.05)。[结论]大肠癌组织中Clusterin高表达,Syk低表达,两者可作为判断大肠癌恶性潜能的生物学指标。

[Purpose] To investigate the relationship of Clusterin and spleen tyrosine kinase （Syk） expression with biological behavior of colorectal carcinoma.[Methods] The expression of Clusterin and Syk in 80 cases with colorectal carcinoma tissue and 80 cases adjacent tissue was detected by immunohistochemical method.[Results] The positive rate of Clusterin in colorectal carcinoma tissue and adjacent tissue was 71.25%（57/80） and 10.00%（8/80）,respectively,with significant difference（P0.01）.The expression rate of Syk in colorectal carcinoma tissue and adjacent tissue was 35.00% （28/80） and 92.50%（74/80）,respectively,with significant difference（P0.01）.The expression of Clusterin was related to differentiation,depth of invasion,TNM stage and lymph node metastasis（P0.05）.The expression of Syk was related to depth of invasion,TNM stage and lymph node metastasis（P0.05）.[Conclusion] Clusterin is overexpression and Syk is low expression in colorectal carcinoma,they may be used as biological indicators for malignant potential of colorectal carcinoma.