盐酸戊乙奎醚治疗慢性肺源性心脏病急性发作期的效果比较

Studying of penehyclidine hydrochloride on patients with acute onset of chronic pulmonary heart disease

目的研究盐酸戊乙奎醚在对慢性肺源性心脏病(肺心病)急性发作期的治疗作用。方法 265例慢性肺心病急性发作期患者随机分为2组:Ⅰ组:给予氧疗、平喘、祛痰、抗感染、抗凝、强心利尿、降低心脏负荷及糖皮质激素等常规治疗。Ⅱ组:在常规治疗基础上加用盐酸戊乙奎醚治疗。对比2组临床疗效。结果显效率:Ⅰ组29.8%,Ⅱ组59%(P<0.01);总有效率:Ⅰ组61.8%,Ⅱ组79.9%,两组比较差异有统计学意义(P<0.05)。住院总病死率:Ⅰ组19.8%,Ⅱ组5.2%(P<0.05)。因呼吸衰竭病死率:Ⅰ组16%,Ⅱ组3.73%(P<0.01)。治疗后临床症状改善时间:Ⅱ组(12±8.8)h,Ⅰ组(30±7.5)h(P<0.01)。结论加用盐酸戊乙奎醚治疗慢性肺源性心脏病急性发作期的疗效优于传统疗法。

Objective To evaluate the clinical effects of routine and Penehyclidine hydrochloride on patients with acute onset of chronic pulmonary heart disease. Methods 265 cases of acute onset of chronic pulmonary heart disease were randomly divided into two groups. Group I was given routine therapy including oxygen - cardiotonics, reduced heart load and renocortical steroid. Group Ⅱ therapy, antispasmodics, antibiotics, anticoagulant, diuretics and was added Penehyclidine hydrochloride besides routine therapy. The clinical effects were compared among the groups. Results The evident effective rates were 29. 8% in group Ⅰ , and 59% in group Ⅱ. The evident effective rates of group Ⅱ were significantly higher than that of group Ⅰ （p 〈 0.01 ）. The overall effective rates were 61.8% in group I ,and 79.9% in group Ⅱ （p 〈0.05）. The hospitalized mortality rates were 19. 8% in group Ⅰ,and 5. 2% in group Ⅱ（p〈0.01）.The time of clinical improvement was 30 ±7.5 hours in group Ⅰ , and 12 ±8.8 hours in group Ⅱ （p 〈0.01） Conclusion The comprehensive effect of combined routine therapy, Penehyclidine Hydrochloride are superior to the conventional therapy on patients with acute onset of chronic pulmonary heart disease.