氨氯地平与替米沙坦对高血压患者颈动脉内-中膜厚度及高敏C反应蛋白的影响

Effect of amlodipine and telmisartan on carotid artery intima-media thickness and serum high-sensitivity C-reactive protein in patients with essential hypertension

目的观察氨氯地平与替米沙坦对高血压患者颈动脉内-中膜厚度(IMT)及高敏C反应蛋白(hs-CRP)的影响。方法将78例高血压合并颈动脉粥样硬化患者随机分为氨氯地平及替米沙坦组。两组分别给予氨氯地平5～10mg/d和替米沙坦40～80mg/d。2组患者均连续服药12个月。在治疗前及治疗后12个月时,测定2组血压、hs-CRP及行颈部血管超声检查。结果 2组在治疗后12个月,血压及hs-CRP与治疗前相比均明显下降;IMT与治疗前相比明显减低,组间比较差异无统汁学意义。结论替米沙坦与氨氯地平有相似的降压及抗动脉粥样硬化作用。

Objective To study the effect of amlodipine and telmisartan on serum high-sensitivity C-reactive protein （hs-CRP） and carotid artery intima-media thickness in patients with hypertension. Methods 78 patients with essential hypertension were randomly divided into（ n = 40） amlodipine and telmisartan group （n = 38 ）. Amlodipine group was treated with amlodipine tablets 5 - 10mg/d and telmisartan group was treated with telmisartan tablets 40 - 80mg/d. Both groups were treated continuously for 12 months. The blood pressure, plasma hs-CRP and carotid artery IMT were measured before and after treatment among all subjects. Results Blood pressure, hs-CRP, IMT were significantly decreased in two groups after treatment. There were no significant difference between amlodipine and tehnisartan groups. Conclusion Amlodipine and telmisartan had good anti-hypertensive effect, and can reduce the inflammatory factor hs-CRP, and thus reverse carotid artery IMT apparently in patients with hypertension.