血清雌激素对绝经后妇女牙周状况的影响

The Influence of Estrogen on Clinical Periodontitis in Postmenopausai Women

目的观察血清雌激素水平对患有牙周病的绝经后妇女的牙槽骨密度、牙周附着丧失量以及探诊出血情况的影响。方法挑选30例绝经7年内患有牙周病的女性,并按其初始血清雌激素水平分为两组,一组为E_2(>40 pg/ml)充足组,16,例;另一组为E_2(<30 pg/ml)缺乏组,14例。基线时,测定所有患者的附着水平,探诊出血情况以及计算机辅助骨密度影像分析值(CADIA),并于1年后再次测定上述指标,观察指标变化。结果两组患者1年后和基线时比较,雌激素充足组,CADIA平均增加0.32±0.06,缺乏组平均减少0.40±0.07(P<0.001);附着丧失增加2mm以上的发生率,充足组为11%,缺乏组为39%(P<0.04);1年后探诊出血率充足组为20%,缺乏组为40%(P<0.1)。结论患牙周病的绝经后妇女,雌激素充足者,有较少的牙槽骨骨量吸收、附着丧失以及较低的探诊出血率。

Objective The purpose of the present study was to analyze the influence of serum estradiol levels on alveolar bone density change, attachment level and bleeding on probing of periodontal disease in postmenopausal women. Methods Thirty postmenopausal women with periodontitis,within 7 years of menopause, were divided into 2 groups, according to their serum estradiol levels, E2-sufficient（ 〉 40pg/ml, n = 16） and E2-deficient （ 〈 30 pg/ml, n = 14）. Some clinical measurements were obtained at baseline and 1 year later, including Attachment lever, Bleeding on probing and CADIA. Results The change of CADIA in E2-slffficient group were （ ＋ 0.32 ± 0.06） ,in E2-deficient group were （ - 0.40 ±0.07 ）, the differences between two groups are significantly （ P 〈 0. 001 ）. The E2-deficient group had more BOP （40%）, compare to E2-sufficient group （20% ,P 〈0. 1 ） ,higher frequency of 〉 2mm AL loss（39% versus 11%, P 〈0.04）. Conclusion These data suggest that E2-supplementation is associated with lower loss in alveolar bone density, a reduced gingival inflammation and a reduced frequency of clinical attachment loss in postmenopausal women.