乙型肝炎影响孕妇产前筛查结果的研究

Second Trimester Prenatal Screening of Pregnant Women for Hepatitis B Results

目的 探讨乙型肝炎（简称乙肝）对于孕妇孕中期产前筛查结果的影响.方法 对14 611例正常孕妇和168例乙肝标志物HBsAg,HBeAg和HBcAb阳性（简称乙肝大三阳）的孕妇、364例乙肝标志物HBsAg,HBeAb和HBcAb阳性（简称乙肝小三阳）的孕妇进行神经管缺陷（NTD）筛查,并且对筛查出的高危NTD进行B超及随访至新生儿出生,评价三组的阳性率及假阳性率.结果 乙肝大三阳的孕妇高危NTD的阳性率为5.4%,假阳性率为5.3%,均高于正常孕妇（0.75%,0.5%）及乙肝小三阳孕妇（0.3%,0.3%）.结论 乙型肝炎是导致孕妇产前筛查结果假阳性率增高的主要原因,建议对于乙肝大三阳的孕妇建立适合的风险判断标准.

Objective To investigate the second trimester prenatal screening of pregnant women for hepatitis B results. Methods 14 611 cases of normal pregnant women and 168 cases of hepatitis B HBeAg -positive pregnant women,364 cases of hepatitis B three positive pregnant women for neural tube defects （NTD） screening were conducted on three groups of high-risk B-NTD birth and followed up to evaluate the positive rates of three groups,the detection rate and false positive rate. Results The hepatitis B HBeAg-positive pregnant women at high risk of NTD was 5.4% ,false positive rate was 5.3 % higher than in normal pregnant women （0. 75 %, 0. 5 % ） and three positive pregnant women （0. 3 0%, 0. 3 % ）. Conclusion Hepatitis B is causes the pregnant woman pre-natal to sieve looks up the result false positive rate markup the primary cause,and suggest that is should establishe the suitable risk judgment standard regarding the Hepatitis B HBeAg-positive pregnant women.