慢性肾功能不全患者血清T_3T_4TSH浓度变化的临床意义

CLINICAL SIGNIFICANCE OF CHANGES OF SERUM T_3 T_4 TSH CONCENTRATIONS IN PATIENTS WITH CHRONIC RENAL INSUFFICIENCY

用放射免疫法对10例慢性肾功能不全患者和20例正常人进行血清T_3、T_4和TSH浓度测定,结果肾功能不全患者血清T_3浓度明显低于正常人(P<0.001),血清T_3浓度与血清BuN、Cr、24小时尿蛋白总量、尿白蛋白、尿β_2-微球蛋白浓度呈明显负相关(P<0.025～0.001),血清T_4、TSH浓度与正常人无显著性差异;尿毒症患者血清T_3、T_4浓度明显低于氮质血症患者(P分别<0.05,<0.025)。说明血清T_3、T_4浓度变化对疗效与预后判断有一定意义。

Serum T_3, T_4, TSH concentrations of 10 patients with chronic renal insufficiency (CRI) and 20 normal cases were determinated with RIA. Serum T_3 concentrations in patients with CRI were significantly lower than those of normal cases (P<0. 001). Serum T_3 concentrations and significant negative relation with serum BUN, Cr, total amount of urine protein within 24 hours, urine albumin and urine β_2-maicroglubin concentrations (P<0. 025 -0. 001). There was no significant statistic difference in serum T_4, TSH con- centrations between the patients and the normal cases. Serum T_3, T_4 con- centrations in patients with uremia were significantly lower than in those with azotemia (P< 0.05, 0. 025, respectively). The changes of serum T_3, T_4 concentrations have important significance in judging therapeutic effect and prognosis in cases of chronic renal insufficiency.