106例洋地黄中毒原因的回顾性分析

RETROSPECTIVE ANALYSIS OF THE CAUSES OF DIGITALIS INTOXICATION IN 106 CASES

为了研讨洋地黄中毒原因,本文对748例洋地黄治疗中106例中毒病例进行了回顾性分析。全组中毒率为14.2％。553例地高辛维持量疗法、106例肾功能不全、49例洋地黄耐量试验、89例伍用异搏定的中毒率依次为7.8、21.7、38.8与16.9％。上述结果提示主要中毒原因是负荷法或维持量疗法用量过大,肾功能不全,药物(如异搏定、乙胺碘呋酮)相互影响,洋地黄耐量试验和心肌耐受性降低。及时发现和适当处理这些原因,可进一步降低洋地黄的中毒率。

To study the causes of digitalis intoxication, 106 digitalis- intoxicated cases from 748 digitalis-treated patients were analysed retrosp- ettively. With a total intoxication rate of 14.3%, the digitalis intoxication rates in 553 cases of digoxin maintenance therapy, 106 cases of kidney dysfunction, 49 casas of digitalis tolerance test and 89 cases of digoxin associating verapamil therapy were 7.8%, 21.7%, 38.8%, and 16.9%, resp- ectively. The result suggests that the leading causes of digitalis intoxication are load therapy, overdose in maintenance therapy, kidney dysfunction, interaction of drugs (such as verapamil, aminodarone, etc.), tolerance test and reduced myocardium tolerance. Reduction of digitalis intoxication rate relies on early identification of the causes and proper management.