期刊文献+

非小细胞肺癌患者血浆中ADM含量与化疗疗效相关性

下载PDF
导出
摘要 目的探讨肾上腺髓质素(ADM)在非小细胞肺(NSCLC)癌患者血浆中的表达及其与化疗疗效的关系。方法采用放射免疫法测定67例NSCLC患者血浆中ADM的含量,然后比较化疗后计分相互关系。结果 Pearson相关分析表明,NSCLC患者疗效记分与血浆ADM含量之间呈负相关(关联系数r=-0.437,P=0.000);NSCLC鳞癌患者疗效记分与血浆ADM含量之间呈负相关(关联系数r=-0.505,P=0.001);NSCLC腺癌患者疗效记分与血浆ADM含量之间呈负相关(关联系数r=-0.410,P=0.034)。结论且ADM的表达水平与NSCLC的临床临床相关。检测NSCLC患者血浆中ADM的含量为肺癌的诊断及预后提供了一种新的方法,也为其治疗提供新的靶点。
作者 易光明
出处 《中国实用医药》 2011年第11期66-67,共2页 China Practical Medicine
  • 相关文献

参考文献9

  • 1Wakelee H,Kemstine K,Vokes E,et al.Cooperative group research efforts in lung cancer 2008:focus on Advanced-stage non-small-cell lung cancer.Clin Lung Cancer,2008,9(6):346-351.
  • 2Harrison JK,Barber CM,Lynch KR,et al.Molecular cloning of a novel rat G-protein-coupled receptor gene expressed prominently in lung,adrenal,and liver.FEBS Letters,1993,318(1):17-22.
  • 3管忠震,梅慰德.肿瘤内科诊治手册.安徽科学技术出版社,2006:184.
  • 4孙燕,汤钊猷译.UICC临床肿瘤学手册.北京:人民卫生出版社,2006:304.
  • 5Kitamura K,Kangawa K,KawamotoM,et al.Adrenomedullin:a novel hypotensive peptide isolated from human pheochromocytoma.Bichem Biophys Res Commun,1993,192:553-560.
  • 6Deville JL,Salas S,Figarella-Branger D,et al.Adrenomedullin as a therapeutic target in angiogenesis.Expert Opin Ther Targets,2010,14(10):1059-1072.
  • 7Ehlenz K,Koch B,Preuss P,et al.High levels of circulating adrenomedullin in severe illness:correlation with C-reactive protein and evidence against the adrenalmedulla as site of origin.Exp Clin Endocri-nol Diabetes,1997,105(3):156-162.
  • 8Garayoa M,Martinez A,Lee S,et al.Hypoxia-inducible factor-1(HIF-1) up-regulates Adrenomedullin expression in human tumor cell lines during oxygen deprivation:a possible promotion mechanism of carcinogenesis.Mol Endocrinol,2000,14:848-862.
  • 9Cuttittia F,Pio R,Garayoa M,et al.Adrenomedullin functions as an important tumor survival factor in human carcinogenesis.Microscopy Research and Technique,2002,57(2):110-119.

共引文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部