邻二甲苯一步法合成邻甲基苯甲腈

ONE STEP SYNTHESIS OF O METHYL BENZONITRILE FROM O XYLENE

以邻二甲苯为原料、苯甲酸盐为催化剂进行液相氧化，一步合成邻甲基苯甲腈。在实验室进行了条件试验，得出了最佳反应条件：反应温度 ４０３ Ｋ，溶剂与原料之比为 ２．５０，反应压力为０．４０ Ｍ Ｐａ，反应时间３．５ ｈ。在上述操作条件下，单程转化率３７．０８％ ，选择性５２．８４％ 。并探讨了该反应的反应机理。

One step synthesis of o methyl benzonitrile with o xylene as raw material and benzene carbonate as catalyst was carried out in liquid phase oxygenation. Under an optimum operating condition of a reaction temperature of 403K, a solvent to raw material ratio of 2.5, a pressure of 0.40Mpa, and a reaction time of 3.5h, the once through conversion was 37.08%, and the selectivity was 52.84%. The reaction mechanism was discussed.