膀胱癌术后热灌注化疗对胰岛素样生长因子、肿瘤坏死因子含量的影响

Influence of intravesical chemotherapy combined with hyperthmia on TNF ,IGF in carcinoma of bladder after TURBt

目的探讨膀胱癌术后进行热灌注化疗对胰岛素样生长因子（IGF）、肿瘤坏死因子（TNF）的影响。方法回顾性分析64例膀胱移行细胞癌患者，术后进行膀胱热灌注化疗（热化疗组）和灌注化疗（化疗组）各32例；治疗前、治疗后2周、治疗后4周监测IGF、TNF的变化。结果治疗前、治疗后2周、治疗后4周热化疗组IGF分别为（65．97±5．25）μg/L、（49．93±1．98）μg/L、（36．82±1．89）μg/L；化疗组IGF分别为（61．87±5．41）μg／L、（57．86±2．18）μg/L、（48．68±2．26）μg/L。热化疗组TNF分别为（2．32±0．36）μg/L、（3．84±0．31）μg/L、（8．79±0．46）μg/L；化疗组TNF分别为（2．21±0．19）μg/L、（2．89±0．47）μg/L、（3．87±0．61）μg/L。热化疗2周对细胞因子浓度的影响比化疗组明显，并随治疗时间的延长其影响愈加明显，差异均有统计学意义（均P〈0．05）。结论热灌注化疗可更好地调节机体的免疫状态，对抑制膀胱癌的生长和复发具有重要意义。

Objective To explore the influence of intravesical chemotherapy combined with hyperthmia on levels of.insulin growth factor（IGF） and tumor necrosis factor（TNF） in bladder cancer after operation. Methods 64 eases of transitional cell carcinoma of bladder accepted TURBt were randomly divided into two groups ： intravesieal chemotherapy combined with hyperthmia group and intravesical chemotherapy group. Levels of IGF and TNF in two weeks before therapy 、 two weeks after therapy 、 four weeks after therapy were tested. Results The IGF levels were （65.97±5.25） μg/L, （49.93 ±1.98） μg/L, （36.82 ± 1.89）μg/L in intravesical chemotherapy combined with hyperthmia group and （ 61.87 ± 5.41 ） μg/L, （ 57.86 ± 2.18 ）μg/L, （ 48.68 ±2.26 ）μg/L in intravesical chemotherapy group. The TNF levels were （ 2.32 ±0.36 ） μg/L, （ 3.84 ± 0.31 ）μg/L, （ 8.79 ± 0.46 ）μg/L in intravesical chemo- therapy combined with hyperthmia group and（ 2.21 ± 0.19 ）μg/L, （ 2.89 ± 0.47 ）μg/L, （ 3.87±0.61 ） μg/L in intravesical chemotherapy group. The influence of intravesical chemotherapy with hyperthmia on levels of IGF and TNF were significant than intravesical chemotherap, and the influence degree showed in time-dependent manner（ all P 〈 0. 05）. Conclusion Intravesical chemotherapy combined with hyperthmia had curative effect in inhibiting the recurrence of tumor after operation.