氨溴索治疗新生儿肺炎65例临床观察

Clinical study of curative effect of ambroxol on the treatment of infectious pneumonia in the newborn

目的观察盐酸氨溴索治疗新生儿感染性肺炎的疗效和安全性。方法将确诊的新生儿感染性肺炎130例按就诊顺序分为对照组和治疗组，每组各65例。对照组采用常规治疗，治疗组加用盐酸氨溴索口服液，每次110—115mg／kg，3次／d，口服，7d后比较两组的临床疗效。结果治疗组肺部哆音消失天数、平均住院天数、需人工吸痰次数均较对照组显著减少，分别为[（2．8±0．8）d和（5．6±1．3）d、（6．3±1．1）d和（7．6±1．9）d、（3．7±1．6）次和（6．2±1．9）次]，两组差异均有统计学意义（t=14．79、4．77、8．11，均t9〈0．05）；治疗组总有效率92．31％，高于对照组的76．92％，两组差异有统计学意义（x^2=5．91，P〈0．05）；观察过程中未发现与氨溴索相关的药物不良反应。结论盐酸氨溴索治疗新生儿感染性肺炎具有显著的疗效和较好的安全性。

Objective To investigate the clinical effect and safety of ambroxol on the treatment of neonates with infectious pneumonia. Methods 130 cases of infectious pneumonia in the newborn were randomly divided into two groups, treatment group and control group, each group 65 patients. The control group received routine therapy, the treatment group took ambroxol in addition,the treatment period were both 7 adys. Results Days of physical signs of lung and hospitalization and demand of sucking phlegm in therapy group were significantly less than those in control group（ all P 〈 0.01 ） ;the treatment group＇s total effective rate was 92.31%, and the control group＇s was 76.92%, there was significant statistical difference between the two groups （ P 〈 0.05）. Conclusion It was significantly effective and safe to use ambroxol in treatment of neonates with infectious pneumonia.