保守治疗对异位妊娠血β-HCG水平的影响

Influence of conservative treatment on the level of serum β-HCG in tubal ectopic pregnancy

目的探讨血β-HCG变化与异位妊娠保守治疗的关系。方法选择确诊的异位妊娠患者95例行甲氨蝶呤（MTX）单次剂量50ms／m^2／周，治疗1～2周，保守治疗成功（B组）87例，失败（A组）8例。治疗同时测定血β-HCG水平。结果B组患者在治疗1～2周后血β-HCG值下降〈15％的病例数明显少于A组，差异有统计学意义（p〈0．05）。结论定期监测血清β-HCG水平变化有助于判定药物治疗的效果，在用药物1～2周后血清β-HCG值下降仍〈15％者，应适时放弃保守治疗尽早选择手术治疗。

Objective To explore the relationship between the change of serum β-HCG and the effect of conservative treatment in tubal ectopie pregnancy. Methods 95 patients with tubal eetopic pregnancy were treated with single dose methotrexate injection. Among them,87 patients were successfully cured, 16 patients were treated with the 2nd dose and Chinese herbal medicine orally;8 patients failed. The change of serum β-HCG levels after the first and 2nd course of treatment were measured. Results It showed that after the first or 2nd course of treatment,the cases which serum β-HCG level reducing less than 15% in patients who had successful treatment were significantly lower than that in patients who failed（ P 〈 0.05 ）. Conclusion Detecting the change of serum β-HCG concentration can e- valuate the therapeutic effect in tubal eetopic pregnancy with conservative treatment, and according that surgical opera- tion should be chosen if serum β-HCG reduce less than 15% after two courses of treatment.