年轻与中老年女性乳腺癌病理特征对照研究

Contrast Analysis of the Different Characteristics Between Very Young and the Middle or Elder Patients with Breast Cancer

目的：分析年轻与中老年女性乳腺癌病理特征差异。方法：回顾分析我院2002年1月~2010年8月收治的64例年龄35岁的年轻乳腺癌患者的临床及病理资料,并与同期所有收治的35岁以上的291例中老年女性乳腺癌进行比较,所有病例均经手术治疗及病理确诊。结果：年轻组占同期收治病例的18.03%;年轻组雌激素受体（ER）或孕激素受体（PR）阳性患者比例低于中老年组差异有统计学意义（P〈0.05）;年轻组无淋巴结转移及ER阴性患者比例高于中老年组差异有统计学意义（P〈0.05）;两组乳腺癌患者中病理组织类型、肿瘤大小、pTNM分期比较,差异均无统计学意义。结论：ER表达、PR表达、淋巴结未转移伴ER阴性的患者年轻组与老年组比较差异有统计学意义（P〈0.05）;年轻女性乳腺癌发病率呈上升趋势,一般认为较年老乳腺癌相比更具侵袭性,预后差。本研究数据显示年轻组占同期收治病例的18.03%,需要提高我区年轻女性对乳腺癌的警惕,加强对乳腺癌知识的宣传教育。

Objective：To analyze the differences of the clinlcopathologic features of breast cancer in young and middle-aged womenMethods： A retrospective study compared the clinical and pathlolgical data of 64 cases of young women（≤35 years）with breast cancer with 291 cases of middle-aged women（35 years）with breast cancer treatde an our hospital from January 2002 to August 2010 All these cases had undergone surgical treatment and been confirmed by pathologist. Results： The young patients（≤35 years）accounted for 18.03% of the diagnosed cases of breast cancer.The proportion of estrogen receptor（ER）or progesterone rerceptor（PR）positive patients in young group was lower than the middle-aged group（P0.05）,The proportion of young patients with non-lymphatic metastasis and ER negative was higher than the middle-aged patients （P0.05）,There were no statistically significant differences between two groups in the pathological types.tumour size and pTNM classification Conclusion： There were statistically significant differences in ER or PR positive and ER negative with non-lymphatic metastasis between young women（≤35 years） showed an increasing tendency.It is generally considered that young patients with breast cancer have more aggressive and poorer prognosis than the middle-agde patients.Our data showed the young patients（≤35 years） account for 18.03% of the diagnosed cases.which indicated that young women should increase awareness of breast cancer in our region and strengthen the propaganda education of breast cancer.