原发性肝癌患者乙型肝炎病毒与丙型肝炎病毒感染标志物的分析

Analysis of serum hepatitis B virus and hepatitis C virus infection markers in patients with primary carcinoma of liver

［ 目的］ 了解原发性肝癌患者乙型肝炎病毒和丙型肝炎病毒的感染状况，并探讨原发性肝癌与乙型肝炎病毒和丙型肝炎病毒的关系．［ 方法］ 用酶联免疫吸附法对８２ 例肝癌患者、８０ 例肿瘤对照组和１０３ 例健康对照组进行了乙型肝炎病毒和丙型肝炎病毒感染标志物的检测．［ 结果］ 肝癌患者中乙型肝炎病毒的感染率为６８ ％ ，显著高于肿瘤对照组（４１ ％ ） 和健康对照组（３８％ ） ．肝癌组中丙型肝炎病毒抗体阳性率为３４ ％ ，显著高于对照组；肝癌组乙型肝炎病毒和丙型肝炎病毒的双重感染率为１７ ％ （１４／８２） ，显著高于肿瘤对照组（３ ％ ） 及健康对照组（２ ％ ） ，乙型肝炎病毒和丙型肝炎病毒的双重感染率在肿瘤对照组和健康对照组之间无显著性差异；乙型肝炎病毒和丙型肝炎病毒的双重感染的比值比为２３－９２ ，显著高于单独乙型肝炎病毒或丙型肝炎病毒感染的比值比，分别为４－６３ 和７－９７ ．肝癌组甲胎蛋白（５０ ～２００μｇ／Ｌ） 低浓度阳性者中占２９ ％ ，显著高于其它２ 个对照组．［结论］ 乙型肝炎病毒和丙型肝炎病毒双重感染能促进原发性肝癌的发生，对乙型肝炎病毒或丙型肝炎病毒感染的慢性肝病患者，或者甲胎蛋白持续低浓度者，应视为原发性肝癌的高危人群，?

OBJECTIVE To study the relation between the infection of hepatitis B virus(HBV), hepatitis C virus(HCV) and primary hepatic carcinoma(PHC).METHODS The serum markers of HBV infection and anti HCV in 82 patients with PHC,80 tumour patients without liver diseases as tumour controls and 103 normal controls were tested by using the methods of enzyme labeled immunosorbent assay.RESULTS The positive rate of HBV (68%) in PHC is significantly higher than that in tumour controls (41%) and normal controls (38%); anti HCV positive rate in PHC (34%) is significantly higher than that in the two controls; infection rate of HBV and HCV in PHC(17%) is significantly higher than that in tumour controls(3%) and normal controls (2%), alpha fetoprotein concentration (50～200μg/L) in PHC is 29%, significantly higher than that in the two control groups.CONCLUSIONS High infection rate of HBV and HCV might exacerbate developing PHC; the chronic liver disease patients with HBV,HCV infection,or alpha fetoprotein continuing at low concentration should be considered as high risk persons,a follow up study for a long time carried out, and diagnosed as early as possible find out patients with PHC.