香菇多糖治疗恶性胸腔积液的临床观察

Clinical observation of Lentinan on malignant pleural effusion

目的:观察胸腔注射香菇多糖治疗恶性胸腔积液的疗效与不良反应。方法:将符合标准的120例恶性胸腔积液患者随机分为两组,治疗组60例,对照组60例,两组均行胸腔穿刺置管闭式引流术,治疗组给予香菇多糖8mg,对照组顺铂40mg,胸腔内注射,每周1次,共3次,观察并记录、分析整个治疗期间的疗效、生活质量和不良反应。结果:两组疗效相当(P>0.05),试验组不良反应发生率低于对照组(P<0.05),生活质量改善率高于对照组(P<0.05)。结论:香菇多糖治疗恶性胸腔积液与顺铂疗效相当,但提高患者生活质量效果更显著,不良反应轻微。

Objective：To observe the clinical effect and adverse reactions of intrapleural perfusion Lentinan in treating malignant pleural effusion.Methods：Total of 120 patients with malignant pleural effusion were randomly divided into two groups,60 cases in the trial group,the other 60 in the control group.Both of the two groups were treated with closed drainage,followed by intrapleural injection of Lentinan 8mg for the trial group,cisplatin 40mg for the control group,once a week,three times.Results：The efficiency of the two groups was similar.There was no significant difference between two groups（P0.05）.Compared the adverse reactions rates,in the trial groupit was lower than the control group（P0.05）.The quality of life improvement rate in the trial group was higher than the control group（P0.05）.Conclusion：Compared with cisplatin,lentinan treatment of malignant pleural effusion is equivalent,but can improve the quality of life in patients and has slight adverse reactions.