维吾尔族、汉族冠状动脉斑块64排螺旋CT特征与危险因素对照分析

Comparison between the characteristics of coronary plaque by 64-slice CT and risk factors in Uygur and Han patients in Xinjiang

目的:比较新疆维吾尔族(维族)与汉族冠心病患者冠状动脉粥样硬化斑块的64排螺旋CT特征与冠心病危险因素,探讨2个民族冠心病发病可能原因。方法:同期64排螺旋CT冠状动脉造影确诊为冠心病的维族患者152例及汉族患者304例,分析其斑块成分、部位、血管狭窄程度及梗阻性斑块(狭窄≥50%的斑块)累及冠状动脉的分支数,并采集患者性别、年龄、身高、体质量及高血压病史、糖尿病病史、吸烟史、家族史,三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平进行比较。结果:维族冠心病患者斑块发生率高于汉族(P<0.05),斑块发生在回旋支的比例高于汉族(P<0.05),斑块引起管腔中、重度狭窄比例高于汉族(P<0.05),梗阻性斑块累及多支比例高于汉族(P<0.05);2个民族斑块成分差异无统计学意义(P>0.05)。维族冠心病患者体质量指数高于汉族(P<0.05),2个民族高血压、糖尿病、吸烟史、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇比较差异无统计学意义(P>0.05)。结论:2个民族冠状动脉粥样硬化斑块特征存在差异,维族冠状动脉粥样硬化斑块发生率高、病变程度较汉族重,可能与维族体质量指数高于汉族有关。

Objective To investigate the possible reasons for coronary artery disease in Uygur and Han patients by comparing coronary CT angiography characteristics of atherosclerotic plaque with risk factors for coronary artery disease.Methods A total of 152 Uygur and 304 Han patients with coronary artery disease confirmed by 64-slice CT coronary angiography were colleted the traditional risk factors of coronary artery disease as the sex,age,height,body mass index,hypertension history,diabetes history,smoking history,family history,triacylglycerol,total cholesterol,high density lipoprotein-cholesterol and low density lipoprotein-cholesterol and were analyzed the composition,location and severity of plaque as well as the number of coronary artery branches involvement in obstructive plaque.Results There was no significant difference in plaque compositions between two ethnic groups（P0.05）.In comparison with Han patients,the incidence of plague and the proportion of plague occurring in the left circumflex branch were higher,lumens stenosis was more severe,the proportion of obstructive plaque（stenosis≥50%） involved multi-branch was higher in Uygur patients（P0.05）.There were no significant differences in coronary artery disease risk factors,as hypertension,diabetes,smoking history,triacylglycerol,total cholesterol,high density lipoprotein-cholesterol or low density lipoprotein-cholesterol between two ethnic groups（P0.05）.The body mass index in Uygur patients was higher than that in Han patients（P0.05）.Conclusion Coronary atherosclerotic plaque characteristics show differences in Uygur and Han patients.The incidence of coronary atherosclerotic plaque is higher and the lesion is more severe in Uygur patients,which may be associated with the fact that body mass index is higher in Uygur patients than that in Han patients.