复发性尿路感染的中西医结合治疗的临床研究

Clinical Study of Combining Traditional Chinese and Western Medicine Treatment in Patients of Recurrent Urinary Tract Infections

目的:探讨中西医结合治疗复发性尿路感染的疗效和安全性。方法:78例复发性尿路感染随机分成两组,中西药组38例和西药组40例。中西药组加用"宁泌泰"。宁泌泰使用方法每次3粒,治疗期每日3次、巩固期每日2次、维持期每日1次连续使用,观察期停药。结果:78例中总治愈69例(88.5%),有效7例(8.9%),无效2例(2.56%)。西药组分别为35例(87.5%)、4例(10%)、1例(2.5%),中西药组分别为34例(89.5%)、3例(7.9%)、1例(2.6%)。中西药组和西药组在治愈率和中段尿细菌培养阳性率无差异。治愈的60例患者总疗程22～118周,平均(50.1±20.6)周。治疗期6～75周,平均(30.48±15.23)周。巩固期4～13周,平均(5.28±2.34)周。维持期12～30周,平均(14.33±3.70)周。二组的治疗期、巩固期、维持期和总疗程时间,中西药组分别为(28.2±10.2)周、(4.3±3.6)周、(14.2±4.6)周、(46.7±10.2)周,西药组分别为(32.4±12.8)周、(5.5±2.2)周、(14.8±3.1)周、(52.7±11.7)周。中西药组和西药组相比,在治疗期、巩固期和维持期时间差异无统计学意义,在总疗程缩短差异有统计学意义(P<0.05)。治疗前后血常规、肝肾功能无明显变化。结论:采用治疗期、巩固期和维持期的分期治疗方法对复发性尿路感染的治愈率高,安全性好,加用宁泌泰的中西药治疗比单用西药其总疗程有所缩短。

Objective：To investigate the efficacy and safe on recurrent urinary tract infection of combining traditional Chinese and western medicine treatment.Methods：78 cases of recurrent urinary tract infections were randomly divided into two groups,Combining traditional and western medicine group of 38 cases Combined with Chinese medicine NingBi tai,and western medicine group of 40 cases.Using the method of NingBi Tai is three goals each time.three times a day During the treatment period,and two times a day in the consolidation period,and once daily in the maintenance period,continuous use,discontinuation in the Observation period.Results：Among 78 patients,69 cases were cured,7 cases were effective,and two cases were the opposite.Western medicine group 35/40、4/40、and1/40respectively,traditional and western medicine group 34/38、3/38、and 1/38 respectively.The cure rate and middle urine germiculture positive of Traditional Chinese and Western medicine group and Western medicine group are no difference.The total treatment time was from 22 weeks to 118 weeks in the cured 60 cases,including treatment period（6 to 75 weeks）,consolidation period（4 to 13 weeks）,and maintenance period（12 to 30 weeks）.The average period of each four stages was（50.1±20.6）weeks,（30.48±15.23）weeks,（5.28±2.34）weeks,（14.33±3.7）weeks.The time of treatment,consolidation,maintain period and total duration,in the traditional and western medicine group were respectively（28.2±10.2）weeks,and（4.3±3.6）weeks,and（14.2±4.6）weeks,and（46.7±10.2）weeks,in the western medicine group were respectively（32.4±12.8）,and（5.5±2.2）weeks,and（14.8±3.1）weeks,and（52.7±11.7）weeks.Compared with western medicine group,the time of the period of total treatment in chinese and western medicine group are statistically distinguishable shortened in statistical differences（P0.05）,without treatment,consolidate and maintenance period.There were no significant changes in blood routine,liver and renal functions among,before and after the treatment.No adverse effect on blood routine,liver and renal function.Conclusion：For recurrent urinary tract infection,the use of the method of stage treatment with several antibiotics has a high cure rate and Combined with the traditional and western medicine with NingBi tai than western medicine,the total treatment is shorter.