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DNA疫苗佐剂 被引量:2

DNA vaccine adjuvants
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摘要 DNA疫苗出现于20世纪90年代,Wolff首先发现携带外源基因的质粒DNA通过肌内注射可以使外源基因在体内表达,这激起了科学家们对DNA疫苗最初的探索,随后Tang等进行了人类历史上首次DNA疫苗实验,由此一个新型疫苗形式诞生了[1-2]。
出处 《中国病毒病杂志》 CAS 2011年第2期83-87,共5页 Chinese Journal of Viral Diseases
基金 国家"十一五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项"创新性复制非复制载体艾滋病疫苗研究"(2008ZX1001-1010)
关键词 DNA疫苗 免疫刺激剂 佐剂 DNA vaccine Immunostimulants Adjuvants
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参考文献58

  • 1Polack FP,Lee SH,Permar S,et al.Successful DNA immu-nization against measles:neutralizing antibody against eitherthe hemagglutinin or fusion glycoprotein protects rhesus ma-caques without evidence of atypical measles. Nature Medicine . 2000
  • 2Hussain I,Kline JN.CpG oligodeoxynucleotides:a novel thera-peutic approach for atopic disorders. Curr Drug TargetsInflamm Allergy . 2003
  • 3Cong YP,Song SS,Bhagat L,et al.Self-stabilized CpG DNAsoptimally activate human B cells and plasmacytoid dendriticcells. Biochemical and Biophysical Research Communications . 2003
  • 4Ioannou XP,Gomis SM,Hecker R,et al.Safety and efficacyof CpG-containing oligodeoxynucleotides as immunological adju-vants in rabbits. Vaccine . 2003
  • 5Wang X,Bao M,Wan M,et al.A CpG oligodeoxynucleotideacts as a potent adjuvant for inactivated rabies virus vaccine. Vaccine . 2008
  • 6Zhang L,Tian X,Zhou F.Intranasal administration of CpGoligonucleotides induces mucosal and systemic Type 1 immuneresponses and adjuvant activity to porcine reproductive and re-spiratory syndrome killed virus vaccine in pigletsin vivo. International Journal of Immunopharmacology . 2007
  • 7Maletto BA,Ropolo AS,Liscovsky MV,et al.CpG oligode-oxinucleotides functions as an effective adjuvant in aged BALB/c mice. Clinical Immunology . 2005
  • 8Yang S,Wang C,Fang X,et al.Fusion of C3d molecule withneutralization epitope (s)of hepatitis E virus enhances anti-body avidity maturation and neutralizing activity following DNAimmunization. Virus Research . 2010
  • 9Zhang Y,Jiang W,Fan Y,et al.Engineering enhancement ofthe immune response to HBV DNA vaccine in mice by the useof LIGHT gene adjuvant. Journal of Virological Methods . 2008
  • 10Pouyanfard S,Bamdad T,Parsania M,et al.Impact of timingstrategy of LIGHT,a new TNF superfamily on immune plat-form induced by HSV-1 gB DNA vaccine. Cytokine . 2010

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