自主研发的毛囊单位样结构可移植假发的组织相容性及长期移植效果的实验研究

A hair prosthesis consisting of allogeneic hair and polypropylene mimicking follicular units:long-term result and histocompatibility in rabbits

目的研发出携带同种异体毛发的毛囊单位样假发可移植物,观察其植入后的组织相容性及长期移植的稳定性,探索其工业化生产并应用于临床的可能。方法将人发和医用聚丙烯按毛囊单位样结构挤压成型,并加工成毛囊单位样假发可移植物。移植于新西兰大白兔,通过HE和电镜扫描观察聚丙烯及人发的组织相容性及长期移植效果。结果移植后早期可见轻度炎症反应细胞浸润于聚丙烯和人发周围,并伴有局部上皮细胞增生。移植后1年仍保持良好的组织相容性,未发现人发的降解。假发一年脱落率为(4.1±4.0)%,毛发仿真外观效果好。结论同种异体人发及聚丙烯均具有良好的组织相容性,移植后外观效果好,脱落率低,具有工业化生产并应用于临床的潜能。

Objective To develop a follicular unit-like construct with allogeneic hair,evaluate its histocompatibility and long-term stability after transplantation,and explore the possibility of its clinical application.Methods Human hair and medical polypropylene was processed according to the structure of follicular units and prepared into hair prostheses for transplantation.The histocompatibility of polypropylene and human hair in New Zealand rabbits was observed by HE staining and scanning electron microscope,and the loss rate of the hair was recorded to evaluate the long-term result of transplantation.Results Mild inflammatory cell infiltration around polypropylene and human hair was observed early after the transplantation,accompanied with local epithelial cell proliferation.The prosthesis mimicking the follicular units still showed good histocompatibility one year after the transplantation without degradation of the hair.The loss rate of the hair was averaged（4.1±4.0）% at one year after the transplantation,and the total appearance of the prosthesis remained satisfactory.Conclusion Allogeneic human hair and polypropylene in the hair prosthesis show good histocompatibility in rabbits.The prosthesis allows good cosmetic effect after transplantation with low rate of hair loss,demonstrating its potential in clinical application.