摘要
AIM:To study the association between hilar cholangiocarcinoma(HC) and pre-existing medical conditions. METHODS:Three hundred and thirteen HC patients admitted to the Eastern Hepatobiliary Surgery Hospital(Shanghai,China) in 2000-2005 and 608 healthy controls were enrolled in this study.Association between HC and pre-existing medical conditions was studied with their adjusted odds ratio(OR) calculated by logistic regression analysis. RESULTS:The prevalence of choledocholithiasis(adjusted OR=2.704,P=0.039) ,hepatolithiasis(adjusted OR=3.278,P=0.018) ,cholecystolithiasis(adjusted OR =4.499,P<0.0001) ,cholecystectomy(adjusted OR =7.012,P=0.004) ,biliary ascariasis(adjusted OR= 7.188,P=0.001) ,liver fluke(adjusted OR=10.088,P =0.042) and liver schistosomiasis(adjusted OR=9.913,P=0.001) was higher in HC patients than in healthy controls. CONCLUSION:Biliary tract stone disease(choledocho-lithiasis,hepatolithiasis,cholecystolithiasis) and parasitic liver disease(biliary ascariasis,liver fluke,liver schistosomiasis) are the risk factors for HC in Chinese population.
AIM：To study the association between hilar cholangiocarcinoma（HC） and pre-existing medical conditions. METHODS：Three hundred and thirteen HC patients admitted to the Eastern Hepatobiliary Surgery Hospital（Shanghai,China） in 2000-2005 and 608 healthy controls were enrolled in this study.Association between HC and pre-existing medical conditions was studied with their adjusted odds ratio（OR） calculated by logistic regression analysis. RESULTS：The prevalence of choledocholithiasis（adjusted OR=2.704,P=0.039） ,hepatolithiasis（adjusted OR=3.278,P=0.018） ,cholecystolithiasis（adjusted OR =4.499,P0.0001） ,cholecystectomy（adjusted OR =7.012,P=0.004） ,biliary ascariasis（adjusted OR= 7.188,P=0.001） ,liver fluke（adjusted OR=10.088,P =0.042） and liver schistosomiasis（adjusted OR=9.913,P=0.001） was higher in HC patients than in healthy controls. CONCLUSION：Biliary tract stone disease（choledocho-lithiasis,hepatolithiasis,cholecystolithiasis） and parasitic liver disease（biliary ascariasis,liver fluke,liver schistosomiasis） are the risk factors for HC in Chinese population.
