不离体酒精浸泡灭活法治疗原发性恶性骨肿瘤

In Situ Alcoholic Devitalization in the Treatment of Primary Malignant Bone Tumor

目的：推荐一种不切断骨在体内酒精灭活治疗原发性恶性骨肿瘤的方法，以缩短治疗周期，延长使用周期和减少骨愈合方面的并发症。方法：利用原发恶性骨肿瘤膝关节上、下高发的特点，解离关节，清除瘤灶，将含瘤骨段套入塑料袋中，并注入９５％ 酒精。灭活后修复缺损的骨，重建关节。共治疗８ 例。结果：获得随访的８ 例，中位时间２３ 个月（８～４２ 个月）。１ 例因软组织复发而截肢，２ 例因肺转移死亡，但无１ 例灭活骨复发，５ 例肢体功能满意。结论：体内酒精灭活治疗原发恶性骨肿瘤是一种较理想的灭活控制局部复发的方法。由于无需骨折愈合。

Objective: To describe the use method of in situ alcohol devitalization in the treatment of primary bone tumor Methods: Eight cases of commonly seen primary bone tumor of the knee region were treated by disarticulation of the knee joint, removal of tumor, exposure of bone stump followed by immerging the tumor containing bone stump in a plastic bag containing 95%alcohol for 40～45 minutes After that the knee joint was reconstructed Results:Eight cases were followed-up for 8 to 42 months (median 23 months) Amputation was performed in one case for soft tissue reccurrence Two cases died of lung metastasis No bone recurrence was observed Perfect limb function was achieved in 5 cases Conclusion: In situ alcohol devitalization provides an ideal treatment of primary malignant bone tumor nearby the knee joint since it does not cut off the tumor bearing bone segment with a shorter recovery time and salvages satisfactory limb function