N-CWS对膀胱癌荷瘤鼠IL-1,IL-2,IL-6及NK活性的影响

The Influence upon the Activity of IL-1, IL-2, IL-6 and NK by Nocardia Rubra Cell Wall Skeleton on Transplantable Bladder Carcinoma in Syngeneic Mice

目的：探讨红色诺卡氏菌细胞壁骨架（Ｎｏｃａｒｄｉａｒｕｂｒａ Ｃｅｌｌ Ｗａｌｌ Ｓｋｅｌｅｔｏｎ，Ｎ－ ＣＷＳ） 对膀胱肿瘤治疗效果和机理。方法：用Ｎ－ ＣＷＳ注射膀胱癌荷瘤鼠，观察Ｎ－ ＣＷＳ的抑瘤效果及Ｎ－ ＣＷＳ对ＩＬ－ １，ＩＬ－ ２，ＩＬ－ ６ 和ＮＫ活性的影响。结果：注射Ｎ－ ＣＷＳ的膀胱癌荷瘤鼠的抑瘤率为９６２ ％ ；肿瘤对照组小鼠ＩＬ－１ ，ＩＬ－ ２，ＩＬ－６ 水平及ＮＫ 细胞活性均明显低于正常小鼠（ Ｐ＜００１） ，提示荷瘤鼠免疫功能受到抑制。Ｎ－ ＣＷＳ组ＩＬ－ １，ＩＬ－ ２ ，ＩＬ－ ６ 水平及ＮＫ 细胞活性则明显高于肿瘤对照组。结论：Ｎ－ ＣＷＳ对膀胱癌具有明显的抑制作用，其机理可能是通过提高机体的ＩＬ－ １ ，ＩＬ－ ２，ＩＬ－ ６ 水平和ＮＫ

Objective: Bladder cancer is one of the most common tumors in urinary system, and its recurrence rate is very high The main causes of so high recurrence rate of bladder cancer include the immunological suppression,the growth of residual, the implanted cancer cells, and the developmental multi-foci in nature Methods: The influence upon the IL-1, IL-2, IL-6 and NK by nocardia rubra cell wall skeleton (N -CWS) were studied on transplantable bladder carcinoma (BST 739 ) in syngeneic T 739 mice Results:The tumor inhibition rate treated by N-CWS was 96 2% The level of the activity of NK of tumor control mice was lower than those from normal mice ( P <0 01), and the level of IL-1, IL-2, IL-6 and the activity of NK treated by N-CWS were higher than those of tumor control mice Conclusion: The results suggest that the immunologic function of transplantable bladder carcinoma in syngeneic mice is suppressed and N-CWS has the immunological enhancement It has good therapeutic effect when the cancer patient be treated by N-CWS Key words Cancer Immunotherapy Nocardia rubra Bladder cancerrol groups.After education,the results showed that level of knowledge on anti schistosomiasis in three groups mentioned above increased significantly,the correct rate of attitude to perform examination and chemotherapy among pupils and adult male men increased remarkably,the qualification rate of value on anti schistosomiasis increased significantly among adult women,and obedience to examination and chemotherapy for schistosomiasis among adult male men increased significantly,frequency of infested water exposure and rate of infection reduced significantly among school children and adult women except adult male inhabitants.Health education can efectively control schistosome infection among pupils and adult women,and increase obedience of examination and chemotherapy for schistosomiasis among adult male men.