糖化血红蛋白和果糖胺的检测在糖尿病诊断中的临床应用

Clinical Application of Detection of Glycated Hemoglobin and Fructosamine in Diagnosis of Diabetes Mellitus

应用Ｋｅｙｓｙｓ 全自动分析仪检测了９６ 例糖尿病患者和６３ 例隐性糖尿病患者的糖化血红蛋白和果糖胺， 并与正常对照组比较。探讨糖化血红蛋白（ＨｂＡｌｃ） 和果糖胺（Ｆｒｕｃ） 的检测在糖尿病诊断中的临床意义。糖尿病组ＨｂＡｌｃ （９－１５±３－８５％）， Ｆｒｕｃ （３３３－４１±９２－７４ μｍｏｌ／Ｌ） 均明显高于正常对照组（ＨｂＡｌｃ：３－４２±０－４１％ ， Ｆｒｕｃ：２０６－０６±２８－５２ μｍｏｌ／Ｌ，Ｐ＜０－０１）。隐性糖尿病组依据空腹血糖无法作出糖尿病的诊断， 而他们的ＨｂＡｌｃ， Ｆｒｕｃ 水平均明显高于正常对照组（ Ｐ ＜ ０－０５） 。糖尿病患者的ＨｂＡｌｃ 与Ｆｒｕｃ 水平具有相关性。ＨｂＡｌｃ， Ｆｒｕｃ 的联合检测对于糖尿病特别是隐性糖尿病的诊断具有重要价值，并可用于指导糖尿病的治疗。

Objective:To study the clinical value of diabetes mellitus diagnos by detecting glycated hemoglobin and fructosamine.Methods:We used Keysys automatical analysers to measure HBA1c and Fruc of 96 cases of diabetes mellituscases,and 63 cases of undetecting diabetes mellitus respectively.Results:HBA1c of diabetes mellitus cases(9 15±3 85%)and Fruc of diabetes mellitus cases(333 41±92 74 μmol/L)were remarkablely higher than the normal control subjects (HBA1c:3 42±0 41%,Fruc:206 06±28 52 μmol/L,p<0 01).Some patients with diabetes mellitus were difficult to be found by fasting blood glucose detection,but their HBA1c and Fruc were remarkably higher than the normal control subjects respectively.The levels of HBA1c and Fruc related to the patients with diabetes mellitus.Conclusions:The simultaneous detections of HBAlc and Fruc have important value for diagnosing diabetes mellitas.