新型战伤急救止血剂体内抗菌活性的实验研究

Study on Antibacterial Ability of the New Type of Hemostat for Combat Injury in Vivo

目的:探讨新型战伤急救止血剂对家兔急性感染伤口的抗菌作用。方法:选用兔感染创面模型,分新型战伤止血剂、5A沸石、Quiclot和空白对照组对创面进行治疗,通过组织学观察、组织内细菌计数等方法对各组抗菌性能进行研究。结果:肉眼和组织学观察新型战伤急救止血剂治疗组动物模型伤口,炎症反应均小于其他各组;新型战伤急救止血剂治疗组织内细菌计数为104,比其他3组显著减少(P<0.01)。结论:新型战伤急救止血剂具有良好的体内抗菌性能。

Objective： To study the antibacterial action of the new type of hemostat for combat injury on the rabbit acute infected wounds.Methods： Adopt the rabbit infection wound model,analytical hemostat for combat injury,5A zeolite,quiclot and the control group to treat the wound.Study the antibacterial properties through the histological observation and the bacterial count methods in the organization.Results： By the naked eye and histological observation of the new type of hemostat for combat injury for acute infected wounds of the rabbits model in the treatment group,the inflammatory reaction was less than that in the other groups.The bacterial count in the treatment group was 104,greatly decreased compared with the other three groups（p0.01）.Conclusions： The new type of hemostat for combat injury has good antibacterial properties in vivo.