SNCG在胃癌中的表达及意义(英文)

Expressions of SNCG in Gastric Adenocarcinoma and Its Clinical Significances

目的:探讨SNCG在胃癌及正常胃粘膜组织中的蛋白和mRNA表达及其与临床病理特征的关系。方法:采用免疫组织化学SP法检测90例胃癌及40例正常胃粘膜组织中SNCG蛋白表达情况,同时应用RT-PCR检测29例胃癌及15例正常胃粘膜组织中SNCG mRNA的表达情况。结果:SNCG蛋白在胃癌组中的表达高于正常胃粘膜组(Uc=7.149,P<0.05),胃癌组中SNCG蛋白阳性表达与癌组织的浸润深度以及有无淋巴结转移有关(Uc=2.742,Uc,3.970,P均<0.05),而与患者的性别、年龄、及癌组织的分化程度无关。SNCG mRNA在胃癌组织中的表达量明显高于正常胃粘膜组织(t=4.399,P<0.01)。结论:SNCG在胃癌组织中的高表达与胃癌发生发展及浸润转移密切相关,可能会成为胃癌早期发现、早期诊断以及判断转移、预后的重要参考指标。

Objective： The purpose of the study was to detect the expressions of SNCG in gastric adenocarcinoma,to evaluate their roles in carcinogenesis,development,infiltration and metastasis as well as their clinical significances.Methods：The expressions of SNCG was detected by SP immunohistochemical method in 90 cases of gastric adenocarcinoma and 40 cases of normal gastric mucosa;The expressions of SNCGmRNA was detected by RT-PCR method in 29 cases of gastric adenocarcinoma 15 cases of normal gastric mucosa.Results：The expression of SNCG protein and SNCG mRNA in the gastric adenocarcinoma were both remarkably higher than those in the normal gastric mucosa（P0.05）;The positive expressions of SNCG protein was correlated with the depth of tumor infiltration and the metastasis of lymph node（P0.05）.Conlusion： SNCG may play an important role in carcinogenesis progression and metastasis of gastric adenocarcinoma and serve as target spots in the targeted therapy of gastric adenocarcinoma.