2型糖尿病患者幽门螺杆菌感染与超敏c反应蛋白、血脂情况的关系

Relationship between hs-C-reactive protein and blood fat and helicobacter pylori infection in type 2 diabetes

目的:探讨2型糖尿病(T2DM)患者幽门螺杆菌(HP)感染与超敏c反应蛋白(hs-CRP)、血脂水平的关系。方法:以2009年1月1日至2009年12月31日在我院体检的683例2型糖尿病患者为研究对象,根据HP感染情况分成HP阳性组(n=306)和HP阴性组(n=377),采用单因素和多因素Logistic回归分析方法,分析HP感染与hs-CRP、血脂水平的关系。结果:(1)HP阳性组的hs-CRP水平高于HP阴性组(1.14mg/L vs 0.96mg/L),差异有统计学意义(P<0.05)。(2)HP阳性组的血脂异常率(59.8%vs 50.7%)和hs-CRP异常率(20.9%vs 14.3%)均高于HP阴性组,差异均有统计学意义(均P<0.05)。(3)单因素Logistic回归分析显示,血脂异常和hs-CRP异常对HP阳性的OR值及分别为1.449和1.582,均有统计学意义(均P<0.05),多因素Logistic回归分析显示,hs-CRP异常对HP阳性的OR值为1.509,有统计学意义(P<0.05)。结论:2型糖尿病患者,HP感染可能通过增高hs-CRP水平,影响脂质代谢,触发一系列生物、生物化学级联反应,可使患者并发心血管病变的风险性增高。

Objective： To explore the relationship between high-sensitivity C-reactive protein（hs-CRP） and Blood Fat and Helicobacter pylori infestation Among Type 2 Diabetes.Methods： A tatol of 683 Type 2 Diabetes who were doing health examination in our sanatorium were included in the present study from January 1st,2009 to December 31st,2009.These individuals were separated into two groups according to the helicobacter pylori（HP） infestation state.One is the HP Positive group（n=306）,the other is the HP Negative group（n=377）.The associations between hs-CRP and Blood Fat and Helicobacter pylori infestation were analyzed by using single and multiple logistic models.Results：（1）The hs-CRP levels in the HP Positive group were higher than the HP Negative group（1.14mg/L vs 0.96mg/L）,the difference has statistical significance,P0.05.（2）The dyslipdemia rates（59.8% vs 50.7%）and hs-CRP abnormity rates（20.9% vs 14.3%） in the HP Positive group were all higher than the HP Negative group,all P0.05.（3）Single Logistic regression analysis manifest that the odds ratio of dyslipdemia and abnomal hs-CRP was 1.449 and 1.582,separately,all P0.05.Multivariate-adjusted odds ratio of hs-CRP was 1.509,P0.05.Conclusion： The HP infection may affect the lipid metabolism through the hs-CRP elevation in Type 2 Diabetes,these will trigger a series of biology or biochemistry cascade reactions which will cause a higher complic risk of vascylopathy in these patients.