复方“自身清”治疗活动性SLE的临床观察

Clinical Observation of Active SLE Treated by Herbal Compound “Self elimination Decoction”

根据滋阴益气、清热解毒法 ,采用复方“自身清”为主治疗活动性系统性红斑狼疮 (SLE) 30例。结果 :治疗 3个月后 ,患者AI评分、Chubick记分及血沉、抗dsDNA抗体均较治疗前有明显下降 (P<0 .0 0 1) ,血小板也有一定程度的增高 (P <0 .0 5) ;患者控制病情平均所需激素量 ,在治疗 6个月后较3个月后及治疗前均明显减少 (P <0 .0 5) ;显效率为4 3 33% ,总有效率达 86 6 7% ,而临床副作用轻微。说明本疗法能控制、缓解SLE活动 ,改善临床症状 ,降低活动性炎症指标 ,减轻SLE体内自身免疫性炎症反应 ,保证激素顺利撤减。

According to nourishing qi and yin,clearing heat and poison methods,herbal compound “Self elimination Decoction” was employed to treat 30 cases with systemic lupus erythematosus(SLE).Results:3 month treatment later,AI score,Chubick score,ESR and anti dsDNA obviously reduced in comparison with pre treatment( P <0.001);thrombocyte increased by certain degrees( P <0.05);after 6 month treatment,the average amount of hormone needed to control the disease significantly lessened compared with those after 3 month treatment and prior to treatment( P <0.05).The markedly effective rate was 43.33% and the total effective rate 86.67%,but the side effects was little.These revealed that this therapy can control and relieve the active SLE,improve clinical manifestations,decrease the level of inflammatory indices and ease the autoimmune inflammatory reaction of SLE to ensure the withdrawal of hormone.