β-防御素在天然免疫中的作用

β-Defensins Function in Innate Immunity

天然免疫系统是宿主抵抗外界病原微生物入侵的重要组织系统。β-防御素是一类富含半胱氨酸和精氨酸的内源性阳离子低分子抗微生物短肽,主要分布于牛的骨髓以及人和多种动物的胃肠道、呼吸道、舌、牙龈、肾、皮肤的的上皮中,是先天性免疫的重要组成部分。β-防御素具有十分广泛的生物活性,对细菌、真菌、病毒、寄生虫等多种病原体都具有杀伤作用,还对免疫细胞有趋化功能,并参与免疫调节,在天然免疫中发挥着重要的作用。

The innate immune system is the important part of host defense system against many common microorganisms.β-defensins are small cationic and cysteine rich endogenous antimicrobial peptides with low molecular weight,which are widely expressed in a variety of epithelials,represent an arm of the innate immune system.β-defensins have various biologic activities and can kill bacteria,fungi,viruses and parasites.They also have chemotactic and regulatory activities and play an important role in the innate immune system.