含ZnS的壳聚糖-阿拉伯胶含药微囊的制备及研究

Preparation and study of Chitosan-Arabic gum microcapsule containing ZnS

目的本文以壳聚糖和阿拉伯胶为囊材,利用复凝聚法制备包裹非甾体抗炎药物布洛芬的微囊,引入ZnS纳米,增强其缓控释性能。方法将含乙酸锌的壳聚糖溶液与含Na2S的阿拉伯胶溶液混合,以布洛芬为模型药物,通过复凝聚法制备包裹非甾体抗炎药物布洛芬的复合微囊,以微囊的药物包封率与载药量为制备工艺优化指标,通过L9(34)正交实验得出微囊的最佳制备工艺条件。同时用转篮法在肠液条件下进行体外溶出的测定。结果壳聚糖浓度为0.2%、成囊pH为4.5、成囊温度为45℃、搅拌速度为200 rpm。交联剂戊二醛用量0.6mL,乙酸锌0.05M,硫化钠0.05M为最佳工艺。引入纳米ZnS的微囊比未引入纳米ZnS的微囊及市售的片剂具有更好的缓控释性能。结论引入纳米ZnS离子,并以最佳制备工艺条件制备含药微囊,工艺稳定,具有良好的缓控释作用。

OBJECTIVE A complex coacervation method was utilized to prepare（Non-steroidal anti-inflammatory drug;NSAID）-Ibuprofen microcapsule using chitosan and Gum-arabic as the wall materials. ZnS was lead into the microcapsule for the fourth generation new dosage forms of sustained and controlled release dosage to build the foundation. METHODS Nanometer microspheres was prepared by Zinc acetate was incorporated into the chitosan liquid and Na2S in the Gum-arabic liquid. By a complex coacervation method to prepare Ibuprofen microcapsule. The orthogonal experimental L9 （34） design using the standard of drug encapsulation was applied to optimize the preparation procedure of the microcapsules. The dissolution rate of microcapsule was assayed by totating basket method. RESULTS The result showed that pH = 4.5, C（chitosan） = 0.2 %, V = 200rpm, T = 45℃ Glutaraldehyde = 0.6mL, the Zinc acetate = 0.05M, Na2S = 0.05M were the best technology. Under the optimum condition, encapsulation= 58.6 %, the ZnS-nanoparticle diameter = 3nm. Lead into ZnS, the microcapsule have better sustained release of drugs than Iibuprofen microcapsuleps and the tablets. CONCLUSION Lead into ZnS, the vitro release of the microcapsules indicate that these microcapsules may prove better sustained release of drugs.