摘要
合成了1-苯基-3-甲基-4-对硝基苯甲酰基-5-吡唑啉酮(简称PMNBP)缩L-缬氨酸甲酯合Ni(Ⅱ)金属配合物,并对合成的配合物进行了红外光谱表征.利用X射线单晶衍射方法测定了配合物的晶体结构,并且利用琼脂扩散法测定了化合物对大肠杆菌和金黄色葡萄球菌的抑制作用.结果表明,配合物对两种细菌的生长均具有一定的抑制作用.最后运用Gaussian03程序,对该配合物进行了量子化学计算.
Complex 1-phenyl-3-methyl-4-（p-nitro）-5-pyrazolone（PMNBP） with L-valine methyl ester and Ni（Ⅱ） was synthesized,and IR was performed.The crystal structure was measured through X-ray diffraction.The antibacterial activity tests of complex against Escherichia coli and Staphylococcus aureus were performed using diffusion test in vitro.The results revealed that the complex had the activity of inhibiting growth of the two bacteriums.Quantum chemistry calculation method was performed on the complex.
出处
《天津师范大学学报（自然科学版）》
CAS
北大核心
2011年第1期57-62,共6页
Journal of Tianjin Normal University：Natural Science Edition
基金
天津市自然科学基金资助项目(70671072)
关键词
席夫碱
配合物
合成
晶体结构
抑菌活性
量化计算
Schiff base
complex
synthesis
crystal structure
antibacterial activity
quantum chemistry calculation
