依普黄酮固体分散体的制备和溶出特性(英文)

Preparation and dissolution property of ipriflavone solid dispersion

目的:制备和鉴定依普黄酮固体分散体,测定它的体外溶出度。方法:用溶剂法制备依普黄酮固体分散体,用DSC,X衍射和红外光谱鉴定固体分散体,浆法测定它的溶出度。结果:由依普黄酮和聚维酮(1:8)组成的固体分散体,其体外溶出度是依普黄酮的6.15倍,DSC曲线,X衍射图谱和红外光谱均产生了明显变化。结论:依普黄酮被制成固体分散体能明显增加依普黄酮的体外溶出度。

AIM: To prepare and identify ipriflavone (IP) solid dispersion, and determine its dissolution property. METHODS: The solvent method was used for preparation and differential scanning calorimetry (DSC), X-ray diffraction and infrared spectrophoto-metry for identification of IP solid dispersion. The dissolution of the dispersion was determined with paddle method. RESULTS: The dissolution of IP solid dispersion consisting of IP and povidone-k30 (PVP) (1 :8) in artificial gastric juice is 6.15 times as high as that of IP alone. The DSC curves, X-ray diffraction patterns and infrared spectrophotometries of IP have been changed obviously by the dispersion. CONCLUSION: The dissolution of IP is increased by solid dispersion method.