祛痛喷雾酊治疗癌性疼痛的临床与实验研究

Clinical and Experimental Studies on Treatment of Carcinomatous Pain by Qu Tong Spraying Tincture

应用祛痛喷雾酊对54例癌痛患者进行镇痛效果的观察,并以强痛定33例为对照组,采用随机对照方法以有效率、疼痛程度、部位、中医辨证分型等指标进行分析。结果治疗组总有效率为79.63％,对照组为72.73％.两组差异无统计学意义(P>0.05)。小鼠醋酸扭体法、小鼠热板法均显示了祛痛喷雾酊的镇痛效果,福尔马林慢性炎症镇痛实验表明;本药具有止痛、消炎、消肿的作用。免疫组化ABC法显示本药对福尔马林大鼠脊髓L_(4～5)节段后角增加SP免疫阳性反应有抑制作用。

Analgesic effect of Qu Tong Spraying Tincture on 54 cases of carcinomatous pain was observed with 33 cases treated by fortanodyn as control. Random control method was used for analysis of effective rate, pain extent, position of pain and TCM syndrome differentiation typing. Results indicated that the total effective rate was 79. 63% in the treated group and 72. 73% in the control group, with no statistically significant difference (P > 0. 05) between the two groups. Both acetic acid twisting method of mouse and hot - plate method of mouse showed analgesic effect of Qu Tong Spraying Tincture, and analgesic experiment on formalin - induced chronic inflammation indicated that the drug had the action of analgesia, anti -inflammation and detumescence. Immunohistologic ABC method showed that the drug had inhibitory action on the formalin - induced increase of SP immunologic positive reaction in posterior horns of L4 - L5 in the rats.