大鼠脊髓受压后的病理学变化

Pathological Changes of Spinal Cord after Compression in the Rat

目的 观察脊髓受压后的病理学变化。方法 通过注射 1 0 6Walker 2 5 6癌细胞液到大鼠 T1 3椎体前 ,建立脊髓硬膜外压迫实验模型。大约 1 6天左右所有动物产生瘫痪 ,快速切取受压处的脊髓组织作透射电镜观察。结果 电镜发现脊髓白质细胞间隙扩大 ,含有外渗的血液细胞 ,并见髓鞘退变。结论 研究提示脊髓受压后的水肿在神经功能障碍的形成中起着重要作用。

Objective To study pathological changes of spinal cord after compression.Methods Extradural spinal cord compression model was induced in Wistar rats by percutaneous inoculation of Walker 256 carcinoma cell suspension (10 6 cells per rat) anterior to T 13 vertebral body.When paraplegia was occurred about 16 days after tumor inoculation,the bolck of compressed spinal cord was taken out for the examination with transmission electron microscope.Results The enlarged interstitial space,degenerated myelin sheath,and extravasated blood cells were found in white matter of the compressed spinal cord.Conclusion Edema in compressed spinal cord plays an important role in the occurrence of neural dysfunction.