静脉注射苯海拉明肾上腺摘除和假手术等预处理对脑伤大鼠肺水肿的影响

Effects of pretreatment with adrenalectomy and benadryl injection on pulmonary edema in rats after head trauma

目的：进一步探讨神经源性肺水肿发病机制。方法：应用头部创伤方法复制大鼠神经源性肺水肿（ＮＰＥ）模型，分别观察全麻加假手术、全麻加肾上腺摘除、全麻加苯海拉明静注加肾上腺摘除等３ 种不同方法的预处理对脑伤大鼠肺部病理改变的影响。结果：全麻加假手术和全麻加肾上腺摘除状态下脑创伤大鼠肺水肿、肺出血等改变最严重；而全麻加苯海拉明静注和肾上腺摘除后脑伤大鼠肺部病变轻微。结论：肾上腺摘除并不能有效地减轻ＮＰＥ的严重程度，而预先应用苯海拉明加两侧肾上腺摘除对脑伤大鼠的肺部有明显保护作用；

Objective:To investigate the potential mechanism(s) concerning neurogenic pulmonary edema (NPE) after trauma.Methods:A NPE model was produced by inflicting head trauma to rats.The effects of pretreatment with general anesthesia (GA) and false operation on adrenal (GA+FO),GA and adrenalectomy (GA+A),and GA and adrenalectomy together with benadryl injection intravenously (GA+A+B) on pulmonary pathological changes were studied in rats after head trauma.Results:It showed that the pulmonary edema and hemorrhage in both GA+FO and GA+A groups were much more severe than in normal control and GA+A+B groups.However,the pulmonary changes in GA+A+B group were mild and similar to those in normal controls.Conclusions:These results suggest that pretreatment with adrenalectomy and benadryl injection but not single adrenalectomy can markedly prevent head injuryinduced pulmonary edema and hemorrhage,and histamine might play an important role in the pathogenesis of NPE.