司帕沙星与洛美沙星的抗生素后效应

THE POST ANTIBIOTIC EFFECTS OF SPARFLOXACIN AND LOMEFLOXACIN

目的：对比研究两种新氟喹诺酮药物司帕沙星（ Ｓ Ｐ Ｌ Ｘ） 和洛美沙星（ Ｌ Ｍ Ｌ Ｘ） 的抗生素后效应。方法：应用 Ａ Ｖ Ａ Ｎ Ｔ Ａ Ｇ Ｅ 自动微生物分析仪的光密度法测定抗生素后效应。结果： Ｓ Ｐ Ｌ Ｘ 和 Ｌ Ｍ Ｌ Ｘ 对 Ｇ＋ 球菌和 Ｇ－ 杆菌均产生明显的后效应，并随抗菌药物浓度的增大，对受试菌的后效应显著延长，呈现明显的浓度依赖性；经ｔ 检验， Ｓ Ｐ Ｌ Ｘ 对金葡菌和大肠杆菌的后效应较 Ｌ Ｍ Ｌ Ｘ 长，对绿脓杆菌的后效应较 Ｌ Ｍ Ｌ Ｘ 短，两药对粪肠球菌的后效应差异无统计学意义。结论： Ｓ Ｐ Ｌ Ｘ 和 Ｌ Ｍ Ｌ Ｘ 均可产生明显的后效应，提示设计给药方案时均应考虑抗生素后效应的因素。

OBJECTIVE:To study the post antibiotic effects(PAEs)of the two new floquinolone drugs——sparfloxacin(SPLX) and lomefloxacin(LMLX).METHODS:The PAEs were determined by the spectrophotometric method using AVANTAGE Microbiology System.RESULTS:Marked PAEs were induced by SPLX and LMLX against gram positive cocci and gram negative bacicci,dose dependently.The PAEs induced by SPLX against S.aureus and E.coli were longer,and the PAEs of SPLX against ps.aeruginosa were shorter than those of LMLX.No statistical significant differences was found on the PAEs of the two drugs against E.faecalis by T test.CONCLUSION:PAEs induced by SPLX and by LMLX were obvious,and suggesting that it should be considered as an important factor in designing dosing schedue of the drugs.