乌拉地尔与特拉唑嗪治疗原发性高血压的比较

COMPARISON OF THE EFFICACY OF URAPIDIL AND TERAZOSIN IN TREATMENT OF ESSENTIAL HYPERTENSION

目的：与特拉唑嗪比较观察乌拉地尔治疗原发性高血压的降压疗效、不良反应。方法：采用随机、开放的方法，观察８０ 例符合 Ｗ Ｈ Ｏ 标准的Ⅰ、Ⅱ期高血压患者。乌拉地尔组５２ 例，６０ ～９０ ｍ ｇ／ｄ 。特拉唑嗪组２８ 例，１ ～８ ｍ ｇ／ｄ 。分早晚服药各１ 次。记录治疗前后血压、心率及不良反应。结果：乌拉地尔和特拉唑嗪显著降低原发性高血压患者的收缩压、舒张压，对心率无影响（ Ｐ＞ ０ ．０５） 。降压疗效比较，乌拉地尔的总有效率达８１ ％ ，特拉唑嗪为６４ ％ 。两组比较无明显差异性。乌拉地尔与特拉唑嗪不良反应的发生率较低，两组比较无差异性。结论：乌拉地尔治疗原发性高血压有显著疗效，无明显不良反应。

OBJECTIVE:To compare the efficacy and side effects of urapidil and terazosin in treatment of mild to moderate essential hypertension.METHODS:The study was conducted in 80 patients with mild to moderate essential hypertension.They were randomly allocated to receive urapidill in a daily dose of 60～90 mg( n =52),or terazosin in a daily dose of 1～8 mg( n =28).RESULTS:BP was significantly reduced in both groups but no changes in heart rate were observed.The total effective rate was 81% for urapidil group and 64% for terazosin group but no significant difference between groups.No obvious side effects were observed in both groups.CONCLUSION:Urapidil is an effective and safe agent for treatment of mild and moderate essential hypertension.