一氧化氮在动物低氧适应中的生理和分子机制

Physiological and Molecular Mechanism of Nitric Oxide in Animal Hypoxia Adaptation

近年来,国内外学者在对高原民族和高原动物低氧适应相关基因的探索中揭示了藏族的低氧适应生理机制;高含量的一氧化氮(nitric oxide,NO)舒张血管并导致高速度的血流,高速度的血流弥补了高海拔低氧。可见一氧化氮在动物低氧适应中起着重要的作用。作者对低氧条件下一氧化氮的合成、传递、生物学效应及调控表达机制进行了综述。

In recent years,hypoxia adaptation-related genetic study of plateau residents and animals has been researched by experts domestic and overseas,and they have revealed its physiological mechanism of Tibetans,which is,a high-flux Nitric oxide（NO） will relax blood vessel and then increase blood flow velocity which offsets the high altitude hypoxia.Obviously,nitric oxide has played an important role in hypoxia adaptation.The authors reviewed its synthesis,transmission,biological effect and its regulation and expression mechanism under the circumstance of hypoxia.