白细胞介素-16的研究进展

Research Progress of Interleukin-16

白细胞介素-16是一种前炎症因子,由CD8+T淋巴细胞分泌,属分泌型蛋白,过去称之为淋巴细胞趋化因子(lym-phocyte chemoattractant factor,LCF),1995正式命名为白细胞介素-16(IL-16)。自从被克隆获得之后,其结构和功能得到广泛的研究,其生物学功能研究也取得了一定的进展。IL-16是多种免疫细胞的趋化因子,参与机体的炎症反应,还与过敏反应、自身免疫系统疾病等其他疾病有关。最近关于IL-16生物活性与临床疾病关系的研究成果比较多,文章对其结构、生物学功能、与疾病的关系及应用加以综述。

Interleukin-16 is a kind of pro-inflammatory cytokines and secretory proteins,secreted by CD8＋T cell.Initially,it was described as lymphocyte chemoattractant factor,officially named as interleukin-16 in 1995.Since it＇s cloned,its structure and function have been researched extensively,besides,there＇s a certain study about its bioactivity.IL-16 is characterized as a chemoattractant for various immune cells,which plays a part in inflammation,allergy,autoimmune and other diseases.Recently,there is much research about the relationship between bioactivity and diseases.So according to current data,this review summarized IL-16 structure,biology function,the relationship between diseases and practical application.