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马来酸氨氯地平的合成研究 被引量:2

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摘要 目的研究高效心血管药物马来酸氨氯地平的合成。方法以N-羟乙基邻苯二甲酰亚胺和4-氯乙酰乙酸乙酯为起始原料,经取代、缩合、加成、水解及成盐反应得到目标化合物。结果经5步反应制得目标化合物,总收率为47.5%。目标化合物结构经IR、1H-NMR、MS等进行了确证。结论与文献方法相比,该合成工艺具有原料易得、反应条件温和、操作简便、收率较高等优点。
出处 《中国医药指南》 2011年第13期49-50,共2页 Guide of China Medicine
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参考文献9

  • 1刘鹤超,冯亚青.新一代心血管药物氨氯地平的合成[J].化学工业与工程,2006,23(1):88-92. 被引量:8
  • 2Campbell SF,Edward CP,Kendrick SJ.Dihydropyridine anti-ischemic and antihypertensive agents,processes for their production and pharmaceutical compositions containing them[P].EP:0089167,1983-09-21.
  • 3Furlan B,CoparA DR.A process for the preparation of amLodipine benzene-sulphonate[P].EP:0599220,1994-06-01.
  • 4Paik W H,Heung LK.Method for the preparation of amLodipine Besylate[P].KR:217240B,1999-09-01.
  • 5Purohit AK,Desai BC.Process for the preparation of anti-ischemic and anti-hypertensive drug amLodipine besylate[P].US:6784297,2004-03-04.
  • 6Vereczkey GD,Biasko G,Simig G.Process for the preparation of adihydropyridine derivative[P].US:6046337A 1,2000-04-04.
  • 7Moon YH,Kim ND.Method for preparing amLodipine[P].US:6492523,2002-09-19.
  • 8Campbell SF,Cross PE,Stubbs JK,et al.Dihydropyridines[P].US:4572908,1986-02-25.
  • 9John EA,Simon FC,Peter EC,et al.Long-acting dihydropyridine calcium antagonists:2-alkoxymethylderivatives incorporating basic substituents[J].J Med Chem,1986,29(9):1696-1702.

二级参考文献11

  • 1CAMPBELL SIMON FRASER, CROSS PETER EDWARD,STUBBS JOHN KENDRICK. Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production,and pharmaceutical compositions containing them [ P ]. EP:0060674A1,1982-09-22.
  • 2BAEK U HYEON, KIM HYEONG GEUN, KIM JI HAN, et al. Method for preparation amlodipine besylate [P]. KR:00217240,1999-06-03.
  • 3ARUN KUMAR PUROHIT, BRAHMADER CHILU DESAL,BALSAHEB DASHRATH SHETE. Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate [P]. US: 2004044218A1,2004-03-04.
  • 4CAMPBELL SIMON FRASER, CROSS PETER EDWARD,STUBBS JOHN KENDRICK. Dihydropyridine anti-ischemicand antihypertensive agents, processes for their production,and pharmaceutical compositions containing them [ P ]. EP:0089167,1983-09-21.
  • 5SIMON F CAMPBELL, PETER E CROSS, JOHN KSTUBBS. 2-(Secondary aminoalkoxymethyl) dihydropyfidine derivatives as anti-sichemic and antihypertensive agents[P]. US:45772909,1986-02-25.
  • 6JERIHA ALENKA, COPAR ANTON DR, FURLANBORUT. A process for the preparation of amlodipine benzenesulphonate [P]. EP: 0599220A1,1994-06-01.
  • 7VERECZKEY GYOERGYI DONATH, BLASKO G ABOR,SIMIG GYULA, et al. Process for the preparation of a dihydropyridine derivative[P]. US: 6046337A1, 2000-04-04.
  • 8YOUNG-HO, KIM NAM-DU, LEE KYUNG-IK, et al.Method for preparing amlodipine [ P ]. US:2002132834A1,2002-09-19.
  • 9LAURA COPPL, YOLANDA GASANZ GULLEN, JULLOCAMPON PARDO. Intermediate for the synthesis of amlodipine,a process for the corresponding use[P]. US:6603006B2,2003-08-05.
  • 10高智平.新型钙拮抗剂-氨氯地平[J].广东药学,1999,9(3):53-54. 被引量:7

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