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海马内注射MK-801对甲醛炎性痛大鼠海马NO含量的影响

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摘要 目的观察海马内给予N-甲基-D-天门冬氨酸(NMDA)受体拮抗剂MK-801对足底注射甲醛诱导的海马一氧化氮生成增加的影响。方法采用硝酸还原酶法测定海马组织NO含量。结果足底注射甲醛后大鼠即出现舔、咬注射侧脚掌等疼痛相关表现,注射甲醛后12h时,海马组织NO含量显著增加;预先海马内注射MK-801,可使甲醛炎性痛大鼠海马组织NO含量明显降低。结论海马内注射MK-801可逆转甲醛炎性痛诱导的海马NO产生的增加,海马内NO生成增加可能与NMDA受体的活动有关。
作者 刘凌云 李欣 李雯
机构地区 上海市杨浦区中心医院神经内科
出处 《中国医药指南》 2011年第13期214-215,共2页 Guide of China Medicine
关键词 海马 一氧化氮 MK-801 疼痛
分类号 R338.3 [医药卫生—人体生理学]
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参考文献10

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共引文献14

中国医药指南
2011年 第13期

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