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微小RNA与卵巢癌铂类耐药的研究进展

MicroRNA in platinum-resistance of ovarian cancer
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摘要 微小RNA（microRNA，miRNA）是广泛存在于生物体内的一类非编码的小RNA，miRNA是细胞增殖、死亡、应激抗性和脂肪代谢的关键调节因素，体外实验已经证实miRNA在卵巢癌耐药中起重要作用。卵巢癌铂类耐药的产生与发展是十分复杂的过程，研究结果显示，miRNA的表达对卵巢癌细胞株的铂类药物敏感性有着重要作用，能够起到耐药性的早期预警作用，改变miRNA表达甚至能够逆转已有的铂类耐药性。但miRNA对耐药相关靶基因调控网络的作用机制不明，需要更多更深入的研究。 MircoRNAs （miRNAs） are widely existing inorganisms, non-coding small RNA. MircoR- NAs play important role in cell proliferation, apoptosis, stress resistance and fat metabolism. In vitro studies indicate that miRNAs are important factors in platinum resistance of ovarian cancer cell lines. However, the pathway of platinum resistance of ovarian cancers is complex. Studies find miRNA expression play important roles in the sensitivity of platinum resistance of ovarian cancer cell lines , and can be used as an early alert for platinum resistance. Changing the expression of miRNA even can reverse the platinum resistance. But the regular role of miRNAs in target genes network is still unconfirmed. Thus, more studies about miRNA in vivo and animal tumor models are needed to identify the function of miRNAs in platinum resistance of ovarian cancer.
作者 程煜 鹿欣
机构地区 复旦大学附属妇产科医院
出处 《国际肿瘤学杂志》 CAS 2011年第5期384-386,共3页 Journal of International Oncology
关键词 微小RNA 卵巢肿瘤 抗药性 肿瘤 MicroRNAs Ovarian neoplasmas Drug resistance, neoplasm
分类号 R737.31 [医药卫生—肿瘤]
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参考文献20

  • 1于海林,姜燕,赵亮,鹿欣.卵巢癌细胞中hCTR1的表达与细胞对顺铂耐药的相关研究[J].肿瘤,2009,29(10):934-939. 被引量：6
  • 2Howell SB,Safaei R,Larson CA,et al.Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs.Mol Phannacol,2010,77(6):887-894.
  • 3Muggia F.Platinum compounds 30 years after the introduction of cis-platin; implications for the treatment of ovarian cancer.Cynecol Oncol,2009,112(1):275-281.
  • 4Borst P,Rottenberg S,Jonkers J.How do real tumors become resistant to cisplatin.Cell Cycle,2008,7(10):1353-1359.
  • 5Garofalo M,Condorelli C,Croce CM.MicroRNAs in diseases and drug response.Curr Opin Pharmacol,2008,8(5):661-667.
  • 6Yang N,Kaur S,Volinia S,et al.MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer.Cancer Res,2008,68(24):10307-10314.
  • 7Yang H,Kong W,He L,et al.MicroRNA expression profiling in human ovarian cancer; miR-214 induces cell survival and cisplatin resistance by targeting PTEN.Cancer Res,2008,68(2):425-433.
  • 8Eitan R,Kushnir M,Lithwick-Yanai C,et al.Tumor microRNA expression patterns associated with resistance to platinum based chemotherapy and survival in ovarian cancer patients.Cynecol Oncol,2009,114(2):253-259.
  • 9Boren T,Xiong Y,Hakam A,et al.MicroRNAs and their target messenger RNAs associated with ovarian cancer response to chemotherapy.Gynecol Oncol,2009,113(2):249-255.
  • 10Van Jaarsveld MT,Helleman J,Berns EM,et al.MicroRNAs in ovarian cancer biology and therapy resistance.Int J Biochem Cell Biol,2010,42(8):1282-1290.

二级参考文献15

  • 1张英丽,鹿欣,丰有吉.铜离子转运蛋白家族与卵巢癌顺铂耐药关系的研究进展[J].现代妇产科进展,2007,16(5):388-390. 被引量：1
  • 2ISHIDA S,LEE J,THIELE D J,et al.Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals[J].Proc Natl Acad Sci U S A,2002,99(22):14298-14302.
  • 3LIN X,OKUDA T,HOLZER A,et al.The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces cerevisiae[J].Mol Pharmacol,2002,62(5):1154-1159.
  • 4SAMIMI S,SAFAEI R,KATANO K,et al.Increased expression of the copper efflux transporter ATP7A mediates resistance to cisplatin,carboplatin,and oxaliplatin in ovarian cancer cells[J].Clin Cancer Res,2004,10 (14):4661-4669.
  • 5SAFAEI R,HOWELL S B.Copper transporters regulate the cellular pharmacology and sensitivity to Pt drugs[J].Crit Rev Oncol Hematol,2005,53 (1):13-23.
  • 6SAMIMI G,VARKI N M,WILCZYNSKI S.Increase in expression of the copper transporter ATP7A during platinum drug-based treatment is associated with poor survival in ovarian cancer patients[J].Clin Cancer Res,2003,9(16):5853-5859.
  • 7NAKAYAMA K,KANZAKI A,TERADA K,et al.Prognostic value of the Cu transporting ATPase in ovarian carcinoma patients receiving cisplatin-based chemotherapy[J].Clin Cancer Res,2004,10 (8):2804-2811.
  • 8MOLLER L B,PETERSEN C,LUND C,et al.Characterization of the hCTR1 gene:genomic organization,functional expression,and identification of a highly homologous processed gene[J].Gene,2000,257 (1):13-22.
  • 9DEVIS S,DAVID J A,HEEJEONG K,et al.Distinct mechanisms for Ctr1-mediated copper and cisplatin transport[J].J Biol Chem,2007,282(37):26775-26785.
  • 10SONG I M,SAVARAI N,SIDDIK Z,et al.Role of human copper transporter CTR1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells[J].Mol Cancer Ther,2004,3 (12):1543-1549.

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国际肿瘤学杂志
2011年 第5期

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