摘要
支气管哮喘是常见的呼吸系统慢性炎症性疾病，糖皮质激素是目前治疗这一疾病最为有效的药物。但有部分哮喘患者因为存在着对糖皮质激素的抵抗而得不到很好的控制。目前已经发现了一些可以导致激素抵抗的分子机制，通过阻断这些机制可能成为临床治疗这一难治性疾病的有效方法。
Bronchial asthma is a common respiratory disease characterized of chronic airway inflammation, which can be effectively treated with glucocorticoids. Nevertheless, there are a small proportion of asthmatic patients fail to respond well to glucocortioids. Some molecular mechanisms of glucocorticoids insensitivity involved in these patients have been investigated. Possibly, these patients could get well controlled through the blockade of one or more pathways of these mechanisms.
出处
《国际呼吸杂志》
2011年第9期696-699,共4页
International Journal of Respiration
基金
基金项目：国家自然科学基金（81070023）
