α,ω-双(2苯-并咪唑)二硫化合物合成工艺的优化

Optimization of Synthesis Method of α,ω-double (2-benzimidazole) Bisulphide

目的优化α,ω-双(2苯-并咪唑)二硫化合物的合成条件。方法以邻苯二胺、二硫化碳为原料,加入四丁基溴化铵作催化剂,在氢氧化钠的碱性条件和氮气保护下经缩合反应和加热闭环生成2苯-并咪唑硫醇钠;然后经氯化制得α,ω-双(2苯-并咪唑)二硫化合物。结果经波谱确证为目标物,总收率90%以上。结论该工艺原料易得,条件温和,产率较高,适合工业化。

Objective To optimize the synthesis conditions of α,ω-（2-benzimidazole） bisulphide.Methods The intermediate 2-benzimidazole mercaptan sodium was prepared from o-phenylendiamine and carbon disulfide through condensation reaction.Then the desired product α,ω-（2-benzimidazole） bisulphide was synthesized from this intermediate via chlorination.Results Its structure was identified by IR,1HNMR,and MS.The total yield was 90%.Conclusion The synthetic method is acceptable for manufacture.