1-氯甲基-6,7-二甲氧基-1,2,3,4-四氢异喹啉盐酸盐的合成和结构表征

Synthesis and Structure Characterization of 1-Chloromethyl-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride

以3,4-二甲氧基苯乙胺为原料,经酰化,比西勒-纳皮拉尔斯基(Bischler-Napieralski)反应,还原,盐酸成盐合成1-氯甲基-6,7-二甲氧基-1,2,3,4-四氢异喹啉盐酸盐,总收率41.1%。目标物及中间体经IR,1H NMR进行结构表征。

1-chloromethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride was synthsized from 3,4-dimethoxy phenethylamine via acylation,Bischler-Napieralski reaction and reduction,then salt formation with muriatic acid,while overall yield was 41.1%,which has not been reported in literatures.The structure of the intermediate and target compounds were characterized by IR and 1H NMR.