诺蒎酸的超声合成

Synthesis of Nopinic Acid under Ultrasound

以β-蒎烯为原料,通过KMnO4氧化辅以超声辐照手段,进行了诺蒎酸的合成条件优化研究。正交实验表明,声强对诺蒎酸的产率影响最大,其次为pH、原料配比、反应温度和时间;单因素实验表明,诺蒎酸的产率随着声强的增大而增大。在声强0.38W/cm2、pH=10、n(β-蒎烯)/n(KMnO4)=1/2、15℃反应30min的优化条件下,合成诺蒎酸的产率达66.4%。

Synthesis of nopinic acid was studied by using β-pinene as raw material and KMnO4 as an oxidant under the assistant of ultrasound.The orthogonal experiments showed that sound intensity greatly influenced the yield of nopinic acid.The other factors were： pH value,the mole ratio of β-pinene and KMnO4,temperature and time.Single factor experiments showed that the yield of nopinic acid was increased as increasing sound intensity.The highest yield observed was 66.4% at the optimum conditions of sound intensity 0.38W /cm2,pH = 10,n（β-pinene） ∶ n（KMnO4） = 1∶ 2,15℃ and 30min.