猴头菌片联合莫沙比利治疗老年功能性消化不良

Hericium Erinaceus Tablet combined Mosapride in treating aged patients with functional dyspepsia

目的评价猴头菌片联合莫沙比利对老年人功能性消化不良(FD)的临床疗效。方法符合功能性胃肠病罗马Ⅲ诊断标准的191例老年FD患者随机分为3组。A组予莫沙比利,B组予猴头菌片,C组二者联合应用,疗程均为6周。分别观察治疗前后症状积分、临床疗效及液体胃排空情况。结果①治疗后各组患者的4种FD症状(餐后饱胀不适、早饱、上腹痛和上腹烧灼感)均明显改善,以C组明显优于A、B两组(P<0.01)。②总有效率:A组76.19%,B组73.02%,C组90.77%。C组疗效与A、B两组比较,差异有统计学意义(P<0.05)。③胃半排空时间:3组均较治疗前缩短(P<0.05),C组缩短最为明显(P<0.01)。结论在莫沙比利治疗基础上联合使用猴头菌片,对老年FD疗效明显。

【Objective】 To evaluate the clinical efficacy of Hericium Erinaceus Tablet combined Mosapride in treating the aged patients with functional dyspepsia（FD）.【Methods】191 patients of over 60 years old and meeting Rome Ⅲ criterion were randomly divided into 3 groups： group A was treated with Mosapride,group B was treated with Hericium Erinaceus tablet and group C was integration of Mosapride and Hericium Erinaceus tablet.The course was 6 weeks.The score of the symptoms,the therapeutic effect,the liquid gastric half emptying function was observed.【Results】The scores of such symptoms as postprandial fullness,early satiation,epigastric pain and epigastric burning were markedly reduced in 3 groups.Group C was superior to the other two in the improvement of symptoms（P 0.01）.The total effective rates in 3 groups were 76.19%,73.02% and 90.77% in order.Compared with group A and B,there was significant difference in group C（P 0.05）.The gastric emptying half-time（GET1/2） of 3 groups was shortened more significantly compared with pretreatment（all P 0.05）,which was most conspicuous in group C（P 0.01）.【Conclusion】 Hericium Erinaceus tablet can be used to promote the therapeutic effects on FD of the aged patients on the basis of Mosapride.